MicrobiologybioRxivPreprint
Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a point mutation in adenylate cyclase with drastic tradeoffs for pathogenicity
Z. Hilbert, K. Chung, J. Bednarek…·N. C. Elde
The paper identifies a point mutation in adenylate cyclase that improves fungal growth in macrophages but reduces disease severity in mice.
DOI 10.1101/2022.09.27.509772