K. Chung

Transdifferentiation of Human Dental Pulp Mesenchymal Stem Cells into Spiral Ganglion-like Neurons

This study differentiates human dental pulp stem cells into spiral ganglion-like neurons using in vitro protocols, showing phenotypic and nanomechanical similarities to native neurons.

Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a point mutation in adenylate cyclase with drastic tradeoffs for pathogenicity

The paper identifies a point mutation in adenylate cyclase that improves fungal growth in macrophages but reduces disease severity in mice.

Integrated platform for multi-scale molecular imaging and phenotyping of the human brain

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

Ultrafast immunostaining of organ-scale tissues for scalable proteomic phenotyping

The paper introduces eFLASH, a method for rapid, uniform labeling of organ-scale tissues, enabling scalable proteomic phenotyping across species and tissues.

The oncogenic Kaposi sarcoma-associated herpesvirus encodes a mimic of the tumor suppressive miR-15/16 miRNA family

This study identifies KSHV miR-K6-5p as a functional mimic of the tumor suppressive miR-15/16 family, showing it inhibits cell cycle progression and promotes growth in KSHV-transformed B cells.

Scalable image processing techniques for quantitative analysis of volumetric biological images from light-sheet microscopy

The paper presents a scalable image processing pipeline for analyzing large volumetric light-sheet microscopy images of mouse brains, improving speed and providing alignment and segmentation tools.

Initial Characterization of the Two ClpP Paralogs of Chlamydia trachomatis Suggests Unique Functionality for Each

This paper characterizes two ClpP paralogs in Chlamydia trachomatis, finding they have distinct expression, interaction, and proteolytic activity patterns.

NINJA-Associated ERF19 Negatively Regulates Arabidopsis Pattern-Triggered Immunity

This study identifies ERF19 as a negative regulator of PTI in Arabidopsis, showing that NINJA represses ERF19 to fine-tune immune responses against pathogens.