Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
15 papers
Recent·Most cited
M. J. W. Schwiesow, L. A. Farinella, M. Ruzic, J. T. Leinas, N. C. Elde, Z. A. Hilbert
This study identifies multiple genetic routes to thermotolerance in Cryptococcus neoformans through experimental evolution under increasing temperatures.
bioRxiv · Apr 8, 2024Microbiology
S. A. Goldstein, T. M. Feeley, K. M. Babler, Z. A. Hilbert, D. M. Downhour, N. Moshiri, N. C. Elde
The paper investigates how evolutionary constraints affect the retention of coronavirus accessory genes through experimental evolution and comparative analysis of SARS-CoV-2.
bioRxiv · Oct 12, 2023Evolutionary Biology
M. C. Rice, N. C. Elde, J. A. Gagnon, K. M. Balla
The paper compares microbes in pet trade and lab zebrafish, identifying a pathogenic birnavirus transmitted from pet shop to lab that causes disease.
bioRxiv · Aug 28, 2023 · PreprintMicrobiology
I. N. Boys, A. G. Johnson, M. Quinlan, P. J. Kranzusch, N. C. Elde
The paper identifies poxvirus-encoded proteins that impact inflammasome-mediated defenses through structural homology screens.
bioRxiv · Feb 26, 2023Evolutionary Biology
Z. Hilbert, K. Chung, J. Bednarek, M. Schwiesow, J. C. S. Brown, N. C. Elde
The paper identifies a point mutation in adenylate cyclase that improves fungal growth in macrophages but reduces disease severity in mice.
bioRxiv · Sep 27, 2022 · PreprintMicrobiology
Z. A. Hilbert, H. J. Young, M. Schwiesow, N. C. Elde
This study identifies rapid evolution in mammalian immune receptors that recognize microbial glycans, revealing host-pathogen conflicts involving fungi and carbohydrate-protein interfaces.
bioRxiv · Sep 7, 2022 · PreprintEvolutionary Biology
S. Jacquet, M. Culbertson, C. Zang, A. El Filali, C. De La Myre Mory, J.-B. Pons, O. Filippi-Codaccioni, M. E. Lauterbur, B. Ngoubangoye, J. Duhayer, C. Verez, C. Park, C. Dahoui, C. M. Carey, G. J. Brennan, , L. Etienne
This study shows that bat PKR genes have evolved through duplication and functional diversification, enabling unique antiviral defenses against DNA and RNA viruses.
bioRxiv · Jun 28, 2022 · PreprintEvolutionary Biology
L. Rheinemann, D. M. Downhour, K. A. Davenport, A. N. McKeown, W. I. Sundquist, N. C. Elde
This study identifies retroCHMP3 as an antiviral defense mechanism that inhibits HIV-1 budding by disrupting the ESCRT pathway, showing distinct evolutionary paths in New World monkeys and mice.
bioRxiv · Apr 27, 2021 · PreprintEvolutionary Biology
S. A. Goldstein, J. Brown, B. S. Pedersen, A. R. Quinlan, N. C. Elde
This study identifies recombination-driven diversification in coronaviruses, revealing unknown genetic diversity that may contribute to future zoonotic threats.
bioRxiv · Feb 3, 2021Evolutionary Biology
S. M. Fixsen, K. R. Cone, S. A. Goldstein, T. A. Sasani, A. R. Quinlan, S. Rothenburg, N. C. Elde
The paper identifies LINE-1 retrotransposition as the mechanism by which poxviruses capture host genes, enabling viral adaptation through rapid duplication of transferred genes.
bioRxiv · Oct 26, 2020Evolutionary Biology
L. Rheinemann, D. M. Downhour, K. Bredbenner, G. Mercenne, K. A. Davenport, P. T. Schmitt, C. R. Necessary, J. McCullough, A. P. Schmitt, S. M. Simon, W. I. Sundquist, N. C. Elde
The paper identifies duplicated and truncated CHMP3 variants in New World monkeys and mice that inhibit enveloped virus budding without affecting essential cellular ESCRT functions.
bioRxiv · Aug 30, 2020Immunology
C. M. Carey, S. E. Apple, Z. A. Hilbert, M. S. Kay, N. C. Elde
The paper investigates how diarrheal pathogens drive evolutionary changes in the GC-C receptor and its ligand in mammals, showing evidence of positive selection and coevolution.
bioRxiv · Mar 29, 2020Evolutionary Biology
K. M. Balla, M. C. Rice, J. A. Gagnon, N. C. Elde
The paper discovers a prevalent picornavirus in zebrafish by using genetically modified fish to visualize immune responses and identifies its widespread tissue tropism.
bioRxiv · Oct 30, 2019Immunology
J. C. Cooper, C. J. Leonard, B. S. Pedersen, C. M. Carey, A. R. Quinlan, N. C. Elde, N. Phadnis
The paper detects recurrent positive selection in mammalian genomes across multiple clades, finding shared selective pressures and highlighting PIGR as a gene involved in a long-term molecular arms race.
bioRxiv · Jun 28, 2019 · PreprintEvolutionary Biology
T. A. Sasani, K. R. Cone, A. R. Quinlan, N. C. Elde
The paper uses long-read sequencing to study poxvirus evolution, revealing a mechanism of adaptive SNV homogenization in gene arrays.
bioRxiv · Jan 9, 2018Evolutionary Biology