M. Tatar

Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin and juvenile hormone

This study shows that gut neuropeptide F (NPF) and its interaction with brain insulin and juvenile hormone regulate Drosophila aging through interorgan communication.

Age-dependent effects of reduced mTor signalling on life expectancy through distinct physiology

This study shows that reducing mTor signaling in old age decreases mortality, while early transient reduction has long-lasting benefits, suggesting age-dependent effects of mTor on aging.

Extra-cellular matrix induced by steroids through a G-protein coupled receptor in a Drosophila model of renal fibrosis

This paper introduces a Drosophila model of renal fibrosis induced by steroids, showing that aldosterone and ecdysone trigger excess extracellular matrix formation through a G-protein coupled receptor, not the canonical nuclear receptor.

The hidden costs of dietary restriction: implications for its evolutionary and mechanistic origins

This study tests evolutionary predictions about dietary restriction in Drosophila, finding mortality costs when returning to rich diets after restriction, challenging current evolutionary explanations of DR.

Drosophila insulin-like peptide dilp1 increases lifespan and glucagon-like Akh expression epistatic to dilp2

This study shows that dilp1 increases lifespan and Akh expression in a dilp2-dependent manner, revealing epistatic interactions between dilp1 and dilp2 in Drosophila aging and metabolism.