S. Liao

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Structures of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features

This study uses cryoET and deep learning to reveal structural differences in the tegument and envelope of EBV and KSHV virions compared to other herpesviruses.

TomoNet: A streamlined cryoET software pipeline with automatic particle picking on flexible lattices

TomoNet is a cryoET software pipeline with automatic particle picking and subtomogram averaging, achieving high-resolution 3D structures from flexible lattices.

Combining Bulk and Single-Cell RNA Sequencing Data to Identify RNA methylation and Autophagy-Related Signatures in Patients with Chronic Obstructive Pulmonary Disease

The paper identifies RNA methylation and autophagy-related genes in COPD using bulk and single-cell RNA sequencing data and validates them in animal models.

The universal suppressor mutation in the HSV-1 nuclear egress complex restores membrane budding defects by stabilizing the oligomeric lattice

The study identifies a suppressor mutation in HSV-1 NEC that stabilizes the hexagonal lattice, restoring membrane budding in various mutants.

StereoSiTE: A framework to spatially and quantitatively profile the cellular neighborhood organized iTME

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

Venom protection by broadly neutralizing antibody from a snakebite subject

This paper identifies a broadly neutralizing antibody from a snakebite survivor that protects against multiple snake venoms by targeting conserved neurotoxin epitopes.

Propagation dynamics of electrotactic motility in large epithelial cell sheets

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 Variants

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

Analysis of variability of functionals of recombinant protein production trajectories based on limited data

The paper develops a bootstrap-based method to infer variability in functionals of protein production trajectories from limited data, applied to time-to-harvest and maximal productivity.

Time dependent proinflammatory responses shape virus interference during coinfections of influenza A virus and influenza D virus

This study shows that influenza A and D viruses interfere with each other during coinfection based on the timing and order of infection, with proinflammatory responses playing a key role.

Ferulic acid combined with skeletal stem cells to repair irradiated bone defect

This study shows that ferulic acid rescues radiation-induced impairments in skeletal stem cells, enhancing bone repair in irradiated defects through MAPK pathway activation.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Lymph flow directs rapid neutrophil positioning in the lymph node in infection

This study shows that lymph flow directs neutrophil migration in lymph nodes during infection by transporting chemokines, and impaired flow leads to persistent infection.

Structural insights into SETD3-mediated histidine methylation on β-actin

This study presents two structures of SETD3 bound to β-actin peptides, revealing sequence-specific recognition and methylation mechanism.

Access COI barcode efficiently using high throughput Single End 400 bp sequencing

The paper introduces a high-throughput sequencing approach to efficiently generate full-length COI barcodes using SE400 data, achieving high accuracy in species identification.

Drosophila insulin-like peptide dilp1 increases lifespan and glucagon-like Akh expression epistatic to dilp2

This study shows that dilp1 increases lifespan and Akh expression in a dilp2-dependent manner, revealing epistatic interactions between dilp1 and dilp2 in Drosophila aging and metabolism.

Phylogenetic relationships in the genus Avena based on the nuclear Pgk1 gene

The paper investigates phylogenetic relationships among Avena taxa using the Pgk1 gene, revealing structural divergence and evolutionary relationships between genomes.