M. V. Ayala

The paper introduces two new mouse models, IgJGFP and IgJCreERT2, for studying plasma cells by leveraging IgJ expression as a marker for antibody-secreting cells.

This study uses high-throughput Ig repertoire sequencing to identify specific mutational patterns in POEMS syndrome, aiding in diagnosis and detection of low-abundance plasma cell clones.

This study develops a mouse model of light chain deposition disease, showing that pathogenic light chains cause glomerulosclerosis and kidney failure, and identifies potential therapeutic targets.