M. Welch

Metabolic specialization drives reduced pathogenicity in Pseudomonas aeruginosa CF clinical isolates

This study shows that metabolic adaptations in Pseudomonas aeruginosa clinical isolates reduce pathogenicity and virulence in cystic fibrosis patients.

Systems-wide dissection of organic acid assimilation in Pseudomonas aeruginosa reveals a novel path to underground metabolism

This study identifies a novel metabolic pathway in Pseudomonas aeruginosa for assimilating organic acids, revealing how enzyme promiscuity enables metabolic adaptation during infection.

Plasma membrane protrusions mediate host cell-cell fusion induced by Burkholderia thailandensis

This study identifies VgrG5 and TagD5 as T6SS-5 effectors that promote cell-cell fusion by acting within plasma membrane protrusions induced by B. thailandensis.

The efficacy of antimicrobial agents is decreased in a polymicrobial environment

This study shows that antimicrobial efficacy decreases in polymicrobial cultures of CF-associated pathogens, with both phenotypic and genetic resistance mechanisms observed.

Distribution and molecular evolution of the anti-CRISPR family AcrIF7

This study investigates the distribution and molecular evolution of the AcrIF7 anti-CRISPR family, identifying sub-clusters, variants, and functional residues.

A genetically encoded, pH-sensitive mTFP1 biosensor for probing lysosomal pH

The paper develops a genetically encoded pH biosensor, FIRE-pHLy, for lysosomal pH measurement and demonstrates its use in cellular models.

Proteomic responses to ocean acidification in the brain of juvenile coral reef fish

This study examines proteomic responses to elevated CO2 in juvenile coral reef fish brains, showing differential protein expression linked to parental behavioural phenotypes and exposure duration.

Contextual flexibility in Pseudomonas aeruginosa central carbon metabolism during growth in single carbon sources

This study investigates how Pseudomonas aeruginosa adapts its central carbon metabolism to different carbon sources, revealing distinct metabolic flux patterns and gene expression changes.

Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially-infected epithelial cells

The paper shows that innate immune signaling triggers mechanical competition, leading to the collective extrusion of infected epithelial cells by uninfected bystanders.

Global reprogramming of virulence and antibiotic resistance in Pseudomonas aeruginosa by a single nucleotide polymorphism in the elongation factor-encoding gene, fusA1.

This study identifies a fusA1 mutation in Pseudomonas aeruginosa that increases antibiotic resistance and alters virulence gene expression through dysregulation of multiple pathways.