M. Grabe

Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site

This paper presents cryo-EM structures of human K2P13.1 (THIK-1) revealing a novel hydrophilic pore restriction and lipid cofactor site, with implications for modulator development.

Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

The paper determines the structure of VGLUT2 with a glutamate analog bound, revealing mechanisms of substrate recognition, electrostatic interactions, and palmitoylation's role in transporter retrieval.

Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A

This study uses molecular dynamics simulations to show that M2 proton channels sense membrane curvature and stabilize negative Gaussian curvature surfaces through symmetry breaking.

Brominated Lipid Probes Expose Structural Asymmetries in Constricted Membranes

The paper uses brominated lipids and cryo-EM to reveal structural asymmetries in constricted membranes.

Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors

The paper identifies a carboxyl-carboxylate clamp motif in transmembrane domains of immune receptors that enables stable assembly and structural diversity through dynamic interactions.

A genetically encoded, pH-sensitive mTFP1 biosensor for probing lysosomal pH

The paper develops a genetically encoded pH biosensor, FIRE-pHLy, for lysosomal pH measurement and demonstrates its use in cellular models.

K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions

This study identifies potassium-dependent conformational changes in K2P2.1 channels that underlie C-type gating, revealing asymmetric order-disorder transitions in the selectivity filter and adjacent loops.

A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms

This paper introduces a computational method to explore alternative mechanisms of molecular machines, finding diverse reaction pathways for cotransport with proofreading capabilities.