Author

P. Brear

Primary ORCID profile (0000-0002-4045-0474 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

P. BreariD3 papers · University of Cambridge

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:metagenomics· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

F. Hollfelder· 2 shared M. Hyvonen· 2 shared A. Lulla· 1 shared A. Wagner· 1 shared A. Wijaya· 1 shared C. Deane· 1 shared C. Wittmann· 1 shared E. Campbell· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

F. Hollfelder

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

K. Fischer, A. Lulla, T. So, P. Pereyra-Gerber, M. I. J. Raybould, T. N. Kohler, T. S. Kaminski, J. C. Yam-Puc, R. Hughes, F. Leiss-Maier, P. Brear, N. J. Matheson, C. Deane, M. Hyvonen, J. Thaventhiran, F. Hollfelder

This paper presents a microfluidics-based method to rapidly discover monoclonal antibodies from antigen-specific antibody secreting cells, achieving high-affinity and neutralizing antibodies against SARS-CoV-2.

bioRxiv · Jan 10, 2023Immunology

Systems-wide dissection of organic acid assimilation in Pseudomonas aeruginosa reveals a novel path to underground metabolism

S. K. Dolan, A. Wijaya, M. Kohlstedt, L. Gläser, P. Brear, R. K. Silva-Rocha, C. Wittmann, M. Welch

This study identifies a novel metabolic pathway in Pseudomonas aeruginosa for assimilating organic acids, revealing how enzyme promiscuity enables metabolic adaptation during infection.

bioRxiv · Aug 25, 2022Microbiology

Functional metagenomic screening in microfluidic droplets identifies a β-glucuronidase in an unprecedented sequence neighbourhood

S. Neun, P. Brear, E. Campbell, T. Tryfona, K. El Omari, A. Wagner, P. Dupree, M. Hyvonen, F. Hollfelder

This study identifies a novel β-glucuronidase from a metagenomic library using microfluidic droplet screening, revealing a new GH3 family member with unique functional and structural properties.

bioRxiv · Apr 25, 2022 · PreprintBiochemistry