An Activator Locks Kv7.1 Channels Open by Electro-Mechanical Uncoupling and Allosterically Modulates its Pore with similarity to phosphatidylinositol-4,5-bisphosphat
M. Moeller, J. A. Schreiber, M. Zaydman, Z. Beller, S. Becker, N. Ritter, E. Wrobel, N. Strutz-Seebohm, N. Decher, J. Cui, N. Schmidt, M. Duefer, B. Wuensch, G. Seebohm
This study identifies two independent mechanisms by which (R)-L3 activates Kv7.1 channels, involving allosteric modulation of the pore and electro-mechanical uncoupling.
bioRxiv · Feb 11, 2021 · PreprintBiophysics