BiophysicsbioRxivPreprint
An Activator Locks Kv7.1 Channels Open by Electro-Mechanical Uncoupling and Allosterically Modulates its Pore with similarity to phosphatidylinositol-4,5-bisphosphat
M. Moeller, J. A. Schreiber, M. Zaydman…·G. Seebohm
This study identifies two independent mechanisms by which (R)-L3 activates Kv7.1 channels, involving allosteric modulation of the pore and electro-mechanical uncoupling.
DOI 10.1101/2021.02.11.430741