ImmunologybioRxivPreprint
Enhanced inflammatory signaling driven by metabolic switch in Aicardi-Goutieres syndrome
M. Batignes, M. Luka, S. Jagtap…·M. M. Menager
This study identifies a metabolic switch and loss of HIF-1 activity in AGS patients, showing that stabilizing HIF-1 reduces inflammation and IP-10 production.