Gut Microbiota-derived Acetate Safeguards the Colonic Epithelial Acetyl-CoA Reserve to Avert Colonic Senescence
Jie Du, Rajesh Sarkar, Lei Wang, Roya AminiTabrizi, Lu Gao, Li Y, Ashley M. Sidebottom, Hardik Shah, Mengjie Chen, Matthew Odenwald, Yan Chun Li
The paper shows that acetate from gut microbiota maintains acetyl-CoA levels in colonic epithelial cells, preventing age-independent senescence and inflammation.
bioRxiv · May 19, 2026 · PreprintPhysiology