PathologyArteriosclerosis Thrombosis and Vascular BiologyPeer-reviewed
Attenuation of Atherosclerosis with PAR4 Deficiency: Differential Platelet Outcomes in apoE-/- vs. Ldlr-/- Mice
Caris A. Wadding-Lee, Megan Jay, Shannon M. Shearer…·Albert Phillip Owens
This study shows that PAR4 deficiency reduces atherosclerosis in Ldlr-/- mice, with effects mediated by hematopoietic cells, particularly platelets, and highlights differences in platelet reactivity between apoE-/- and Ldlr-/- models.
5 citations