Dong Li

This study uses super-resolution imaging to show that IFT complexes in C. elegans cilia dynamically dissociate with age, leading to reduced IFT velocity and ciliary dysfunction.

This study shows AIM2 forms DNA-induced condensates that drive immune activation and regulation through inflammasome and PANoptosome assembly.

This study shows that Spef1 undergoes liquid-liquid phase separation to facilitate non-centrosomal microtubule assembly by enriching tubulins, with its coiled-coil domain mediating this process.

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

The paper introduces NEMOer, a set of genetically encoded calcium indicators that enhance the detection of ER/SR calcium dynamics, enabling sensitive and dynamic imaging in both excitable and non-excitable cells.

This paper introduces a time-lapse image super-resolution neural network with confidence quantification for optical microscopy, improving temporal consistency and reliability.

This study identifies how CAMSAP3 dimerizes via its C-terminal alpha-helix to stabilize non-centrosomal microtubule minus ends through enhanced CKK domain binding.

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

This study identifies distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility, showing Kif6 is a motile cilia-specific IFT motor while Kif9 regulates the central apparatus.

This study identifies USP8's role in endosome maturation by mediating Rab5-to-Rab7 switch through recruitment by Rabex5 and promotion of SAND-1/Mon1 recruitment.

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

This paper introduces SFE-Net and SFT-DFCAN to estimate and correct optical aberrations in live-cell imaging without additional hardware, achieving fast and accurate super-resolution.