Michael Sterr

MAFA drives pancreatic islet maturation through coordination of cell growth, metabolic maturation, and resilience to stress.

This study shows that MAFA promotes pancreatic islet maturation by enhancing cell growth, metabolic function, and stress resilience in stem cell-derived islets.

Resolving human α versus β cell fate allocation for the generation of stem cell-derived islets

The paper investigates human α and β cell fate allocation in stem cell-derived islets, revealing a distinct regulatory mechanism compared to mice and identifying pharmacological strategies to enhance cell fate commitment.

The Human Pancreas Cell Atlas defines a healthy reference framework for disease contextualization and translational benchmarking

The paper constructs a healthy human pancreas reference atlas to contextualize disease states and benchmark models.

Benchmarking porcine pancreatic ductal organoids for drug screening applications

This study benchmarks porcine pancreatic ductal organoids (PPDO) against human pancreatic ductal organoids (HPDO) and primary porcine pancreas using scRNA-Seq, showing PPDO's potential for drug screening with conserved toxicity profiles.

Endocrine-enriched stem cell-derived islets improve long-term safety in vivo

This study improves the safety of stem cell-derived islets by enriching endocrine cells and reducing off-target cell types, enhancing long-term in vivo outcomes.

Mapping cells through time and space with moscot

moscot unifies optimal transport for temporal, spatial and spatiotemporal single-cell mapping, using multimodal cost spaces and low-rank solvers to scale to 1.7 million mouse embryo cells.

Single-cell multiome uncovers differences in glycogen metabolism underlying species-specific speed of development

The paper identifies glycogen metabolism differences in pluripotent cells across species that influence neural differentiation speed.

Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice

This study shows chronic intermittent fasting impairs β-cell maturation and function in adolescent mice, but not in adults, with similar patterns observed in human type 1 diabetes.

Capture of Post-Pluripotency Human Neuromesodermal and Neural Tube Axial Stem Cell States

The paper captures two human axial stem cell states and identifies regulatory networks and mechanisms underlying their maintenance and differentiation.

Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas

This paper integrates multiple scRNA-seq datasets to create a mouse islet atlas, revealing new insights into β-cell states and differences across diabetes models.

Hypercaloric diet triggers transient molecular rearrangements of astrocytes selectively in the arcuate nucleus

This study shows that a hypercaloric diet causes temporary molecular changes in astrocytes specifically in the arcuate nucleus of the hypothalamus.

Wnt/PCP-primed intestinal stem cells directly differentiate into enteroendocrine or Paneth cells

The paper identifies Wnt/PCP-activated Lgr5+ intestinal stem cells that directly differentiate into enteroendocrine or Paneth cells, challenging previous models of multipotency.

Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2.

This study shows that Foxa2 binding site selection is influenced by chromatin environment and that chromatin opening requires collaboration with other transcription factors during endoderm differentiation.