Valerie Vandenbempt

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

The paper constructs a healthy human pancreas reference atlas to contextualize disease states and benchmark models.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.

The paper uses volumetric imaging and single-cell RNAseq to study human dental pulp responses during tooth decay, identifying cellular mechanisms and progression stages.

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.