BiochemistryNature Structural & Molecular BiologyPeer-reviewed
Structural basis of the mechanism and inhibition of a human ceramide synthase
Tomas C. Pascoa, Ashley C. W. Pike, Christofer S. Tautermann…·David Bryant Sauer
This study determines the structural mechanism of CerS6, a ceramide synthase, using cryo-EM and biochemical analysis, revealing a ping-pong reaction mechanism and insights into fumonisin B1 inhibition.
29 citations