N. Banholzer

CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sites

This study uses super-resolution microscopy to show CARs form nanodomains on T-cell membranes, accumulating at tumor sites, with transposon-engineered CARs showing higher density and faster anti-tumor activity.

Is mRNA decapping activity of ApaH like phosphatases (ALPHs) the reason for the loss of cytoplasmic ALPHs in all eukaryotes but Kinetoplastida?

The paper investigates whether mRNA decapping by ALPHs is restricted to Kinetoplastida or widespread in eukaryotes, finding that most eukaryotes have non-cytoplasmic ALPHs with decapping activity.