M. Hudecek

Comprehensive Model of Cell-to-Cell Cytokinin Transport Reveals A Specific Mode of Cytokinin Riboside Influx

The paper identifies a specific membrane transport system for cytokinin ribosides and shows its impact on shoot development.

Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia

This study develops CAR T cells targeting a specific mutation in CLL to selectively kill cancer cells while sparing healthy B cells.

Depletion of alloreactive B cells by chimeric alloantigen receptor T cells with drug resistance to prevent antibody-mediated rejection in solid organ transplantation

This paper develops CORA-T cells to selectively eliminate alloreactive B cells and prevent antibody-mediated rejection in solid organ transplantation.

CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sites

This study uses super-resolution microscopy to show CARs form nanodomains on T-cell membranes, accumulating at tumor sites, with transposon-engineered CARs showing higher density and faster anti-tumor activity.

Solid tumor-on-chip model for efficacy and safety assessment of CAR-T cell therapy

This paper presents a solid tumor-on-chip model to assess CAR-T cell therapy efficacy and safety, showing CAR-T cells exhibit enhanced tumor infiltration and cytokine release, with potential for patient stratification.

TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation

This study shows TCR/CD3-based synthetic antigen receptors (TCC) have superior antigen sensitivity and activation fidelity compared to second-generation CARs.

Genomic Analyses of SLAMF7 CAR-T Cells Manufactured by Sleeping Beauty Transposon Gene Transfer for Immunotherapy of Multiple Myeloma

This paper characterizes the genomic safety of SLAMF7 CAR-T cells produced using Sleeping Beauty transposon technology for multiple myeloma treatment, showing safe integration and no residual transposase.

Inefficient ZAP70-Signaling Blunts Antigen Detection by CAR-T-Cells

This study identifies that inefficient ZAP70 signaling in CAR-T-cells reduces antigen detection sensitivity compared to TCRs.