S. Kramer

Intron-loss in Kinetoplastea correlates with a non-functional EJC and loss of NMD factors

This study shows that Trypanosoma brucei lacks a functional EJC and NMD pathway due to intron loss and gene redundancy.

Beyond BioID: Streptavidin outcompetes antibody fluorescence signals in protein localization and readily visualises targets evading immunofluorescence detection.

This paper demonstrates that streptavidin-based imaging outperforms immunofluorescence in detecting low-abundance or inaccessible proteins and reveals dynamic protein interactions.

High-content fluorescence bioassay to investigate pore formation, ion channel modulation and cell membrane lysis induced by venoms

This paper develops a fluorescence-based high-content assay to identify venom-induced cellular activities like membrane lysis, pore formation, and ion channel modulation across different cell types.

OPEN leaf: an open-source cloud-based phenotyping system for tracking dynamic changes at leaf-specific resolution in Arabidopsis

OPEN leaf is an open-source cloud-based phenotyping system for tracking dynamic leaf-specific changes in Arabidopsis, demonstrating the utility of VIS sensors in high-throughput screens.

Is mRNA decapping activity of ApaH like phosphatases (ALPHs) the reason for the loss of cytoplasmic ALPHs in all eukaryotes but Kinetoplastida?

The paper investigates whether mRNA decapping by ALPHs is restricted to Kinetoplastida or widespread in eukaryotes, finding that most eukaryotes have non-cytoplasmic ALPHs with decapping activity.

The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei

This study identifies Hel66, a DExD/H box helicase, as essential for ribosome biogenesis in Trypanosoma brucei, showing its role in translation and rRNA processing.

Integrated cycles for urban biomass as a strategy to promote a CO2-neutral society - A feasibility study

This paper evaluates the feasibility of integrating closed biomass cycles into residential buildings to achieve CO2 neutrality, showing technical viability but higher costs compared to revenues.

A novel SNF2 ATPase complex in Trypanosoma brucei with a role in H2A.Z-mediated chromatin remodelling

This study identifies and characterizes a SWR1-like chromatin remodeller complex in Trypanosoma brucei that mediates H2A.Z incorporation and is essential for Pol II-dependent transcription.

A metagenomic-based stufy of two sites from the Barbadian reef system

The paper analyzes the microbiome of two Barbadian coral reef sites using metagenomic sequencing to compare microbial community composition in relation to environmental factors.

Parallel monitoring of mRNA abundance, localisation and compactness with correlative single molecule FISH on LR White embedded samples

The paper introduces LR White smFISH to monitor mRNA abundance, localisation, and compactness in dense structures, using trypanosomes as a model system.