N. Bolli

ZEB1 shapes AML immunological niches suppressing CD8 T-cell activity while fostering Th17 cell expansion.

This study shows ZEB1 in AML suppresses CD8 T-cells and promotes Th17 cells, contributing to immune suppression and tumor progression.

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

The paper reconstructs the evolutionary history of therapy-related myeloid neoplasms using chemotherapy-associated mutational signatures and identifies distinct mutational patterns linked to different chemotherapies.

Whole genome sequencing provides evidence of two biologically and clinically distinct entities of asymptomatic monoclonal gammopathies: progressive versus stable myeloma precursor condition

The paper uses whole genome sequencing to identify two distinct myeloma precursor conditions, progressive and stable, based on genomic features.

CD40 provides immune privilege to the bone marrow hematopoietic niche

This study shows that CD40 on bone marrow mesenchymal stem cells (BM-MSCs) promotes immune tolerance and prevents graft-versus-host disease by regulating Treg function and B-cell development.

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

This study reconstructs the genomic evolution of multiple myeloma by analyzing 67 genomes from 30 patients and public datasets, identifying 7 subgroups defined by distinct driver mutations and chronological patterns of genomic events.