Metastatic site influences driver gene function in pancreatic cancer
K. M. Tsanov, F. M. Barriga, Y.-J. Ho, D. Alonso-Curbelo, G. Livshits, R. P. Koche, T. Baslan, J. Simon, S. Tian, A. N. Wuest, W. Luan, J. E. Wilkinson, I. Masilionis, N. Dimitrova, C. A. Iacobuzio-Donahue, , S. W. Lowe
This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.
bioRxiv · Mar 17, 2024 · PreprintCancer Biology