T. Baslan

Metastatic site influences driver gene function in pancreatic cancer

This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.

Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression

The paper investigates how 9p21.3 deletions in cancer disable both cell intrinsic and extrinsic tumor suppression by co-deleting CDKN2A/B and type I interferons, leading to immune evasion and metastasis.

Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease

This study develops somatic mouse models of gastric cancer that replicate human disease subtypes and reveal genotype-specific metastatic patterns and immune interactions.

MYC controls metastatic heterogeneity in pancreatic cancer

This study identifies MYC as a key driver of metastatic heterogeneity in pancreatic cancer by linking its activity to increased metastasis through TAM recruitment.

Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition

This study shows that leukemia cell of origin affects apoptotic priming and sensitivity to LSD1 inhibitors, with Evi1 modulating p53 stability and activity.

Stag1 and Stag2 regulate cell fate decisions in hematopoiesis through non-redundant topological control

The paper shows Stag2 loss in HSPCs impairs B-cell lineage commitment by reducing chromatin accessibility, while Stag1 cannot restore this function despite rescuing topological domains.

DNAJB1-PRKACA fusion kinase interacts with β-catenin and liver regenerative response to drive fibrolamellar hepatocellular carcinoma

This study shows that the DNAJB1-PRKACA fusion kinase drives fibrolamellar hepatocellular carcinoma in mice and identifies β-catenin activation and environmental factors as contributors to tumor progression.