Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism.
L. Espada, A. Dakhovnik, P. S. Chaudhari, A. Martirosyan, L. Miek, T. Poliezhaieva, Y. Schaub, A. Nair, N. Doering, N. Rahnis, O. Werz, A. Koeberle, J. Kirkpatrick, A. Ori, M. Ermolaeva
This study shows that late-life metformin treatment reduces cell survival and lifespan by impairing energy metabolism, contrasting its beneficial effects in early life.
bioRxiv · Dec 3, 2019 · PreprintPhysiology