Cell BiologybioRxiv
Cystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells A mechanistic connection between the kidney defects in cpk mice and human ARPKDRunning title: Cystin deficiency results in FPC degradation
Y. Zhang, C. Yang, W. Wang…·Z. Bebok
This study shows cystin deficiency reduces fibrocystin (FPC) levels in mouse renal cells, leading to proteome changes and cyst formation similar to ARPKD.
DOI 10.1096/fj.202300100r