Author

N. Holguin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:imaging· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Assay:multiome· 1

Frequent Co-Authors

N. Bhadouria· 2 shared P. Niziolek· 2 shared A. G. Berman· 1 shared A. G. Robling· 1 shared A. Hecht· 1 shared A. Lai· 1 shared A. Seifert· 1 shared D. Edwards· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPathology

N. Bhadouria

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization-An In Vivo Rat Model

D. Wang, A. Lai, J. Gansau, A. Seifert, J. Munitz, K. Zaheer, N. Bhadouria, Y. Lee, P. Nasser, D. Laudier, N. Holguin, A. Hecht, J. C. Iatridis

bioRxiv · Jan 27, 2023Pathology

Suppression of sost/sclerostin and dickkopf-1 promote intervertebral disc structure in mice

T. M. Kroon, P. Niziolek, D. Edwards, E. L. Clinkenbeard, A. G. Robling, N. Holguin

This study shows that suppressing sclerostin or dkk1 promotes intervertebral disc structure by enhancing Wnt signaling, but sclerostin also reduces cellular stress pathways.

bioRxiv · Jul 1, 2021 · PreprintBioengineering

Raloxifene reduces sex- and age-related intervertebral disc degeneration in mice by estrogen signaling

N. Bhadouria, P. Niziolek, O. El Jordi, A. G. Berman, D. McKinzie, J. M. Wallace, N. Holguin

This study shows raloxifene improves intervertebral disc structure and reduces substance P in mice by estrogen signaling, counteracting age and sex-related degeneration.

bioRxiv · Jun 29, 2021 · PreprintBioengineering

LRP5-deficiency in OsxCreERT2 mice models intervertebral disc degeneration by aging and compression

M. Silva, N. Holguin

This study shows that LRP5-deficiency in osterix-expressing cells leads to intervertebral disc degeneration, reduced WNT signaling, and decreased expression of key markers in aged and compressed discs.

bioRxiv · Jul 31, 2019 · PreprintBioengineering