Cell BiologybioRxiv
Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth
M. Liu, P. Arvan, J. Sun…·D. A. Ostrov
This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.
DOI 10.2337/db19-1106