Author

D. Larkin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

L. Haataja· 2 shared P. Arvan· 2 shared A. Anjum· 1 shared A. Arunagiri· 1 shared A. C. Almeida· 1 shared A. J. Pereira· 1 shared B. Dhayalan· 1 shared D. A. Ostrov· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

L. Haataja

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4 papers

Recent·Most cited

Differences in pathways contributing to thyroid hormone effects on postnatal cartilage calcification versus secondary ossification center development

S. Mohan, G. A. Gomez, P. Aghajanian, S. Pourteymoor, D. Larkin

This study investigates how thyroid hormone affects cartilage calcification in the proximal femur versus secondary ossification center development in the distal femur, identifying distinct molecular pathways.

bioRxiv · Jan 7, 2022Physiology

Kinetochore-mediated microtubule assembly and Augmin-dependent amplification drive k-fiber maturation in mammals

A. C. Almeida, J. Oliveira, D. Drpic, L. Cheeseman, J. Damas, H. A. Lewin, D. Larkin, P. Aguiar, A. J. Pereira, H. Maiato

The paper investigates k-fiber maturation in mammals, revealing that Augmin promotes microtubule formation and amplification from kinetochores, essential for spindle assembly.

bioRxiv · Aug 18, 2021Cell Biology

Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes

M. Alam, A. Arunagiri, L. Haataja, M. Torres, D. Larkin, J. Kappler, N. Jin, P. Arvan

This study shows that a proinsulin mutation increases susceptibility to diet-induced diabetes in mice, with severity linked to genetic dosage and beta-cell dysfunction.

bioRxiv · Jun 1, 2021Cell Biology

Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth

M. Liu, P. Arvan, J. Sun, Y. Xiong, X. Li, L. Haataja, W. Chen, S. A. Mir, R. Madley, D. Larkin, A. Anjum, B. Dhayalan, N. K. Rege, N. D. Wickramasinghe, M. A. Weiss, , D. A. Ostrov

This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.

bioRxiv · Oct 1, 2019Cell Biology