Author

D. A. Ostrov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Anjum· 1 shared A. Chopra· 1 shared A. J. Keeley· 1 shared A. Sette· 1 shared B. B. Lindsey· 1 shared B. Dhayalan· 1 shared C. N. Mavian· 1 shared COVID-19 Genomics UK (COG-UK) consortium· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCell Biology

A. Anjum

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintApr 10, 2020

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level

S. Leary, S. Gaudieri, M. D. Parker…·S. Mallal

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.

DOI 10.1101/2020.04.10.029454

humanwhole-genome sequencing

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintMar 30, 2020

Recombination and purifying selection preserves covariant movements of mosaic SARS-CoV-2 protein S

M. S. Tagliamonte, N. Adid, D. A. Ostrov…·C. N. Mavian

The paper analyzes SARS-CoV-2 evolution and structure to show recombination and purifying selection shape the S glycoprotein's function and efficiency in human infection.

DOI 10.1101/2020.03.30.015685

humanmouse

𝕏 PostBluesky

Cell BiologybioRxivOct 1, 2019

Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth

M. Liu, P. Arvan, J. Sun…·D. A. Ostrov

This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.

DOI 10.2337/db19-1106

humanproteomics

𝕏 PostBluesky