Olfactomedin-4+ neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection.
A. D. Huber, S. Jose, A.-F. Kassam, K. Weghorn, M. Powers-Fletcher, D. Sharma, A. Mukherjee, A. Mathew, N. Kulkarni, S. Chandramouli, M. Alder, R. Madan
This study identifies OLFM4+ neutrophils as pathogenic determinants of intestinal epithelial damage during Clostridioides difficile infection using single-cell transcriptomics and pre-clinical models.
bioRxiv · Aug 21, 2023 · PreprintImmunology