D. Sharma

VISUALIZING GAUSSIAN-CHAIN LIKE STRUCTURAL MODELS OF HUMAN alpha-SYNUCLEIN IN MONOMERIC PRE-FIBRILLAR STATE: SOLUTION SAXS DATA AND MODELING ANALYSIS

The paper uses SAXS data and modeling to analyze the conformational ensemble of monomeric pre-fibrillar human alpha-synuclein, concluding a shifting equilibrium of curved models with low alpha-helical content.

The β2-adrenergic receptor (ADRB2) entrains circadian gene oscillation and diurnal responses to virus infection in CD8+ T cells

This study shows that the β2-adrenergic receptor regulates circadian gene oscillation and daily timing of cytolytic T cell responses to virus infection.

A putative rhamnogalacturonan-II CMP-β-Kdo transferase identified using CRISPR/Cas9 gene edited callus to circumvent embryo lethality.

The paper identifies a putative rhamnogalacturonan-II CMP-β-Kdo transferase by using CRISPR/Cas9 to generate a callus mutant lacking Kdo, which disrupts RG-II crosslinking and growth.

Monocot-specific miR528 act as the post-transcriptional regulator of strigolactone signaling via Dwarf 3 in rice

This study identifies miR528 as a monocot-specific miRNA that regulates strigolactone signaling in rice by post-transcriptionally targeting OsD3, affecting plant growth and stress responses.

Natural killer cell regulation of breast cancer stem cells mediates metastatic dormancy.

This study identifies natural killer cell regulation of breast cancer stem cells as a key factor in metastatic dormancy using immunocompetent mouse models.

Olfactomedin-4+ neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection.

This study identifies OLFM4+ neutrophils as pathogenic determinants of intestinal epithelial damage during Clostridioides difficile infection using single-cell transcriptomics and pre-clinical models.

Analytical Method Development for Evaluation of Pharmacokinetics and Tissue Distribution of Thiourea-Based Antivirals through nLC/MS-MS

The paper develops a sensitive nLC-MS/MS method to quantify thiourea derivatives in plasma and tissues of rats, showing good linearity and precision.

Safety Assessment and Evaluation of Novel Thiourea Derivatives as Antivirals

This paper evaluates the safety of three thiourea derivatives (DSA-00, DSA-02, DSA-09) as antivirals, finding they are non-cytotoxic, non-mutagenic, and have moderate acute toxicity.

CHRONO participates in multi-modal repression of circadian transcriptional complexes

This paper identifies CHRONO as a repressor of the circadian clock by modulating interactions between BMAL1 and PER2, revealing its role in fine-tuning circadian rhythmicity.

Dehydration alters transcript levels in the mosquito midgut, likely facilitating rapid rehydration

This study shows dehydration alters midgut gene expression in Aedes aegypti, enabling faster rehydration after bloodfeeding and potentially affecting pathogen transmission.

Structural and functional characterization of Rv0792c from Mycobacterium tuberculosis: identifying small molecule inhibitors against GntR protein.

This study characterizes Rv0792c, a GntR homolog from M. tuberculosis, identifies small molecule inhibitors, and reveals its role in stress adaptation and virulence.

Moving patronin foci and growing microtubule plus ends direct the spatiotemporal dynamics of Rho signaling and myosin during apical constriction

This study shows microtubule growth regulates Rho signaling and myosin dynamics during apical constriction in Drosophila, influencing tissue contraction.

Epigenetic regulation of epithelial dectin-1 through an IL-33-STAT3 axis in allergic disease

This study identifies an IL-33-STAT3 axis that epigenetically represses dectin-1 in epithelial cells, contributing to allergic disease.

IL-4 receptor targeting as an effective immunotherapy against triple-negative breast cancer

This paper demonstrates that DABIL-4, a fusion toxin targeting IL-4R, effectively reduces TNBC tumor growth and metastasis by depleting both tumor cells and immunosuppressive cells in the tumor microenvironment.

The kinetic landscape of an RNA binding protein in cells

This study introduces a method to measure RNA-protein binding kinetics in cells and shows that Dazl binds RNA sites briefly but influences mRNA levels through clustered binding.

miRNA-encoded peptide, miPEP858, regulates plant growth and development in Arabidopsis

The paper identifies miPEP858a, a peptide encoded by pri-miR858a, and shows it regulates plant growth, development, and flavonoid biosynthesis through modulation of miR858a and its target genes.