PhysiologybioRxivPreprint
PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome
S. Mishra, V. Hahn, N. Sadagopan…·D. A. Kass
This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.