Author

N. Said

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. Wang· 3 shared I. Artsimovitch· 3 shared T. Hilal· 3 shared M. C. Wahl· 2 shared M. Finazzo· 2 shared A. G. Camacho· 1 shared A. T. Kovacs· 1 shared B. Loll· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

B. Wang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A pervasive large conjugative plasmid mediates multispecies biofilm formation in the intestinal microbiota increasing resilience to perturbations

L. Garcia-Bayona, N. Said, M. J. Coyne, K. Flores, N. M. Elmekki, M. Sheahan, A. G. Camacho, K. Hutt, F. H. Yildiz, A. T. Kovacs, M. K. Waldor, L. E. Comstock

The paper identifies a large conjugative plasmid that promotes multispecies biofilm formation in the gut microbiota, enhancing resilience to environmental stressors.

bioRxiv · Apr 29, 2024 · PreprintMicrobiology

Sm-like protein Rof inhibits transcription termination factor Rho by binding site obstruction and conformational insulation

N. Said, M. Finazzo, T. Hilal, B. Wang, T. L. Selinger, D. Gjorgjevikj, I. Artsimovitch, M. C. Wahl

This study identifies Rof as an inhibitor of the transcription termination factor Rho, showing it blocks Rho's activity through structural obstruction and conformational changes.

bioRxiv · Aug 30, 2023Biochemistry

Transcription termination factor {rho} polymerizes under stress

B. Wang, N. Said, T. Hilal, M. Finazzo, M. C. Wahl, I. Artsimovitch

This study shows that Escherichia coli {rho} forms higher-order oligomers under stress, linking transcription termination to cellular physiology.

bioRxiv · Aug 18, 2023Microbiology

Concerted transformation of a hyper-paused transcription complex and its reinforcing protein

P. K. Zuber, N. Said, T. Hilal, B. Wang, B. Loll, J. Gonzlez-Higueras, C. A. Ramirez-Sarmiento, G. A. Belogurov, I. Artsimovitch, M. Wahl, S. H. Knauer

This paper reveals how RfaH activates virulence gene expression by transforming its structure and stabilizing paused transcription complexes through interactions with ops hairpins.

bioRxiv · Jun 26, 2023Biochemistry

SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic beta-cells

L. Hu, F. He, M. Huang, Q. Zhao, L. Cheng, N. Said, Z. Zhou, F. Liu, Y.-S. Dai

This study shows SPARC enhances insulin secretion by reducing RGS4 in pancreatic beta-cells, improving glucose tolerance in SPARC-deficient mice.

bioRxiv · Jan 11, 2020Cell Biology