L. Hu

Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections

The paper examines how sequential Omicron infections affect ancestral SARS-CoV-2 immune imprinting, finding that it persists on the RBD but not the NTD.

Biologically-informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post-treatment glioblastoma

This paper develops BioNet, a biologically-informed deep learning model, to predict intratumoral heterogeneity in post-treatment glioblastoma using MRI and biopsy data, showing improved performance over existing methods.

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging

This paper introduces a microfluidics-based thrombus profiling assay that detects intensified biomechanical thrombogenesis in hypertension and aging, revealing a GPIb-integrin mechanosensing axis hyperactivity mechanism.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

Altered gut microbial functional pathways in people with Irritable Bowel Syndrome enable precision health insights

The paper develops gut microbial functional pathway scores from metatranscriptome data to identify molecular markers associated with irritable bowel syndrome and its subtypes.

FtsZ-mediated spatial-temporal control over septal cell wall synthesis

This paper shows FtsZ treadmilling acts as a template and conveyor to organize cell wall synthesis during bacterial division, with roles changing over time.

Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

This study uses single-cell transcriptomics to identify cell type-specific immune responses in a mouse model of allergic contact dermatitis, highlighting the role of dermal fibroblasts in type-1 inflammation.

Comparison and Evaluation of Neutralization of Clinically Frequently Used Antimicrobial Agents Using Three Different Culture Media in Simulated Blood Cultures

This study evaluates three blood culture media for antimicrobial neutralization, finding BACT/ALERT media outperformed others in recovery rates, while Thermo media had the lowest performance.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Comparative reservoir competence of Peromyscus leucopus, C57BL/6J, and C3H/HeN for Borrelia burgdorferi B31

This study compares the ability of three rodent species to support Borrelia burgdorferi infection and transmission, finding higher bacterial burdens in laboratory mice and reduced transmission from white-footed deermice.

Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice

This study shows that inhibiting Mst1 in endothelial cells reduces acute lung injury in mice by suppressing inflammatory responses and NF-κB activation.

The crystal and cryo-EM structures of PLCγ2 reveal dynamic inter-domain recognitions in autoinhibition

The paper determines crystal and cryo-EM structures of PLCγ2 in autoinhibited states and bound to FGFR1 kinase domain, revealing dynamic inter-domain interactions in autoinhibition.

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

Futile wound healing drives mesenchymal-like cell phenotypes in human glioblastoma

The paper identifies a wound response state in glioblastoma that is shared across malignant and non-malignant cells and is spatially confined to the tumor bulk.

Structure of Orthoreovirus RNA Chaperone σNS, a Component of Viral Replication Factories

This paper determines the structure of the reovirus σNS RNA chaperone and shows how its oligomeric state and N-terminal arm regulate RNA binding and chaperone activity.

Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

The paper identifies replication stress as a driver of BRCA1-deficient breast tumorigenesis in luminal progenitors, showing ELF3 upregulation promotes this process.

Integrated Epigenetic and Transcriptomic Profiling Reveals Dynamic Regulatory Networks Driving Retinoblastoma Pathogenesis

This study uses single-cell multi-omics to map epigenetic and transcriptomic changes in retinoblastoma, identifying key regulators and potential drug targets.

A novel method for sampling subgingival microbiome - a comparative metatranscriptomic study

The paper develops a novel subgingival microbiome sampling method using supragingival swabs and validates it through metatranscriptomic analysis showing comparable microbial profiles to direct subgingival samples.

Shoot maturation strengthens FLS2-mediated resistance to Pseudomonas syringae

The paper shows that FLS2-mediated resistance to Pseudomonas syringae strengthens with shoot maturation through microRNA156 regulation of callose deposition.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Distinct function of SPL genes in age-related resistance in Arabidopsis

This study identifies SPL genes, particularly SPL10, as activators of age-related resistance in Arabidopsis during vegetative phase change by enhancing the salicylic acid pathway.

Machine learning prediction of cancer cell metabolism from autofluorescence lifetime images

This paper uses machine learning on autofluorescence lifetime images to predict metabolic pathway usage in cancer cells, achieving 95% accuracy in distinguishing glycolytic and oxidative metabolism.

The direct interaction with transcriptional factor TEAD4 implied a straightforward regulation mechanism of tumor suppressor NF2

This study identifies a direct interaction between NF2 and TEAD4, showing NF2 inhibits TEAD4 stability and function, revealing a new mechanism of NF2's tumor suppressor role via the Hippo pathway.

Metals and metal isotopes in insect wings: Implications for diet, geolocation and pollution exposure

This study investigates metal and metal isotope composition in monarch butterfly wings to assess dietary sources, environmental contamination, and geolocation potential.

Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode

This paper identifies a new class of TEAD-YAP inhibitors with a novel binding mode that suppresses transcriptional activity and shows anti-proliferative effects in cancer cells.

A common mechanism of temperature-sensing in thermoTRP channels

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

3'UTR-dependent dynamic changes in TP53 mRNA localization regulate p53 tumor suppressor activity

This study shows that 3'UTR sequences of TP53 mRNA regulate its localization and activity by modulating CK2 phosphorylation and AMPK2/HuR dynamics.

Factors that affected the qualification of standardized residency training of internal medicine: a prospective longitudinal study

This study evaluates factors affecting the qualification rates of standardized internal medicine residency training in China, identifying regional origin and training duration as independent predictors.