Author

N. Sofos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. Montoya· 3 shared S. Stella· 3 shared a. fuglsang· 2 shared T. Pape· 2 shared A. Carabias del Rey· 1 shared A. Fuglsgang· 1 shared B. Hove-Jensen· 1 shared B. Lopez-Mendez· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

G. Montoya

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Author profile →

4 papers

Recent·Most cited

Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon

F. Tenjo Castano, N. Sofos, B. Lopez-Mendez, a. fuglsang, L. Stutzke, S. Stella, G. Montoya

The paper presents the cryo-EM structure of the TnsB transposase-DNA complex from a type V-K CRISPR-associated transposon, revealing its architecture and catalytic mechanism.

bioRxiv · Aug 5, 2022 · PreprintBiochemistry

Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase

S. K. Amstrup, N. Sofos, J. L. Karlsen, R. B. Skjerning, T. Boesen, J. J. Enghild, B. Hove-Jensen, D. E. Brodersen

This study reveals how PhnJ mediates ATP hydrolysis-induced structural changes in the C-P lyase complex, uncovering a novel ABC dimer configuration.

bioRxiv · Jun 9, 2022Biochemistry

Structure of the mini-RNA-guided endonuclease CRISPR-Cas{Phi}3

A. Carabias del Rey, A. Fuglsang, P. Temperini, T. Pape, N. Sofos, S. Stella, S. Erlendsson, G. Montoya

This paper determines the cryoEM structure of CRISPR-Cas{Phi}3, revealing its DNA targeting and cleavage mechanism, and shows how it enables unspecific ssDNA degradation.

bioRxiv · Jun 27, 2021Biochemistry

Structures of the Cmr-βComplex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas

N. Sofos, M. Feng, S. Stella, T. Pape, A. Fuglsgang, J. Lin, Q. Huang, Y. Li, Q. She, G. Montoya

This study reveals how target RNA binding regulates Cmr-β complex activities through conformational changes, enabling immune responses against genetic invaders.

bioRxiv · Jun 24, 2020Biochemistry