S. Stella

Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon

The paper presents the cryo-EM structure of the TnsB transposase-DNA complex from a type V-K CRISPR-associated transposon, revealing its architecture and catalytic mechanism.

Structure of the mini-RNA-guided endonuclease CRISPR-Cas{Phi}3

This paper determines the cryoEM structure of CRISPR-Cas{Phi}3, revealing its DNA targeting and cleavage mechanism, and shows how it enables unspecific ssDNA degradation.

DeepFRET: Rapid and automated single molecule FRET data classification using deep learning

DeepFRET automates smFRET data classification using deep learning, achieving >95% accuracy and speed compared to human operators.

Structures of the Cmr-βComplex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas

This study reveals how target RNA binding regulates Cmr-β complex activities through conformational changes, enabling immune responses against genetic invaders.

Collective radioresistance of T47D breast carcinoma cells is mediated by a Syncytin-1 homologous protein

The paper shows that T47D breast cancer cells in clusters are more radioresistant than isolated cells due to a Syncytin-1 homologous protein involved in intercellular bridges.

Structure Of The Cpf1 Endonuclease R-Loop Complex After Target DNA Cleavage

This paper determines the crystal structure of FnCpf1 after DNA cleavage, revealing how it unwinds DNA and processes the PAM sequence.