IRAK4 autophosphorylation controls inflammatory signaling by activating IRAK oligomerization
N. Srikanth, R. Deliz-Aguirre, D. K. Gola, M. Bilay, E. Ziska, M. J. Taylor
This study shows IRAK4 auto-phosphorylation activates IRAK oligomerization, controlling inflammatory signaling by promoting DD domain assembly and downstream IL-1 signaling.
bioRxiv · Dec 21, 2023 · PreprintImmunology