R. E. Campbell

This paper develops a photocaged lactate derivative to locally perturb lactate concentrations and study its roles in metabolism and signaling.

This paper develops an optogenetic method to release single molecules in live cells, enabling controlled delivery of functional proteins and reconstitution of cellular functions at the single molecule level.

The paper introduces a new fluorescent protein, LSSmApple, and uses it to create a genetically encoded calcium sensor for yeast imaging.

The paper develops high-performance genetically-encoded green fluorescent biosensors for intracellular L-lactate and demonstrates their utility in live-cell imaging.

The paper develops a red fluorescent biosensor for extracellular L-lactate, addressing spectral overlap issues of previous green biosensors.

The paper develops a FRET pair using mScarlet-derived green fluorescent protein (mWatermelon) and mScarlet-I for biosensors, enhancing FRET efficiency through intramolecular association modulation.

The paper describes the development of a genetically encoded fluorescent K+ biosensor, GINKO2, optimized for sensitivity and specificity in vivo across multiple species.

The paper introduces PEAQ biosensing, a method using photochromic single-fluorophore biosensors to measure absolute analyte concentrations or activities in live cells.

The paper analyzes nine red GECIs to determine the factors causing Ca2+-dependent fluorescence changes, finding three distinct classes based on their mechanisms.

The paper develops and validates a new red fluorescent calcium indicator, K-GECO1, based on a circularly permutated RFP from a sea anemone, tested across multiple cell types and organisms.