Methylglyoxal-derived glycation tunes nuclear viscoelasticity
Mar Alcaraz-Hurtado, Alysson Duchalet, Angélica Salinas-Torres, Enkela Musliu, Gabriel Jordanov, Jorge Rodriguez-Ramos, Roberto Silva‐Rojas, Natacha Fourny, Óscar Mauricio Bautista Aguilera, Miquel Adrover, Jorge Alegre‐Cebollada, Luc Bertrand, Andra C. Dumitru
This study shows that methylglyoxal-derived glycation increases nuclear stiffness and alters mechanosensitive signaling in cells and tissues.
bioRxiv · Oct 2, 2026 · PreprintBiophysics