Luc Bertrand

This study shows that methylglyoxal-derived glycation increases nuclear stiffness and alters mechanosensitive signaling in cells and tissues.

This study shows that platelet GARP activates TGF-β1 to limit inflammation and promote cardiac repair after myocardial infarction.

This study identifies O-GlcNAcylation and reduced glycolysis as key factors in Th2 polarization by dendritic cells, showing their role in immune synapse regulation and TCR signaling.

This study shows that SMIT1 promotes cardiac hypertrophy and fibrosis in mice under pressure overload by enhancing IP3/Ca2+-dependent signaling pathways.

This study identifies skNAC as critical for maintaining cardiomyocyte integrity and preventing heart failure by regulating proteome homeostasis and metabolic adaptation during pathological hypertrophy.

This study shows that structured alignment of cardiomyocytes improves mitochondrial function and bioenergetic efficiency, highlighting the role of cellular organization in heart health.

This study shows metformin protects the heart from chronic intermittent hypoxia by activating AMPK2, which phosphorylates and inhibits HIF-1α, reducing mitochondrial damage.

This study identifies a NRF2/beta3-adrenoreceptor axis that enhances antioxidant defenses and metabolic rewiring via the pentose-phosphate pathway, protecting cardiac function under stress.

The paper shows that PS1 and PS2 deficiency in primary neurons and astrocytes does not cause mitochondrial dysfunction, contrasting with findings in immortalized cell lines.