Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas
A. R. Daniel, C.-L. Lee, C. Su, N. T. Williams, Z. Li, J. Huang, O. Lopez, L. Luo, Y. Ma, L. D. S. Campos, S. R. Selitsky, J. L. Modliszewski, S. Liu, Y. M. Mowery, D. M. Cardona, D. G. Kirsch
This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.
bioRxiv · Oct 28, 2022Cancer Biology