Author

E. Hanssen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 2 Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Assay:cryo-EM· 2 Assay:electronic health records· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

H. G. Brown· 3 shared M. W. Parker· 2 shared S. Ghosh· 2 shared V. Rajagopal· 2 shared A. Behren· 1 shared A. Chung· 1 shared A. Hammet· 1 shared A. Hickey· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiophysics

H. G. Brown

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Opposing roles of resident and infiltrating immune cells in the defence against Legionella longbeachae via IL-18R/IFN-γ/ROS axis

L. M. Oberkircher, V. M. Scheiding, H. L. Rafeld, E. Hanssen, J. N. Hansen, M. J. Fleischmann, N. M. Kessler, D. Pitsch, D. Wachten, W. Kastenmueller, A. S. Brown, E. Hartland, I. R. van Driel, G. Z. Ng, N. Garbi

This study identifies opposing roles of tissue-resident alveolar macrophages and infiltrating neutrophils/monocyte-derived cells in controlling Legionella longbeachae infection via the IL-18R/IFN-γ/ROS pathway.

bioRxiv · Jan 31, 2024 · PreprintImmunology

Vgamma9Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

T. S. Fulford, C. Soliman, R. G. Castle, M. Rigau, Z. Ruan, O. Dolezal, R. Seneviratna, H. G. Brown, E. Hanssen, A. Hammet, S. Li, S. J. Redmond, A. Chung, M. A. Gorman, M. W. Parker, , A. P. Uldrich

The paper reveals that Vgamma9Vdelta2 T cells recognize BTN2A1 and BTN3A1 heteromers through dual epitope engagement, uncovering a new mechanism of immune activation.

bioRxiv · Aug 30, 2023Immunology

Fitting a square beam in a square camera: novel condensor apertures for low-dose transmission electron microscopy

H. G. Brown, D. Smith, B. C. Wardle, E. Hanssen

This paper introduces square and rectangular condenser apertures for TEM to improve sample area efficiency in low-dose applications, demonstrating compatibility with cryo-TEM.

bioRxiv · Aug 13, 2023Biophysics

Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant

R. D. Metcalfe, E. Hanssen, K. Y. Fung, K. Aizel, C. C. Kosasih, C. O. Zlatic, L. Doughty, C. J. Morton, A. P. Leis, M. W. Parker, P. R. Gooley, T. L. Putoczki, M. D. W. Griffin

This study presents cryo-EM and crystal structures of the IL-11 signalling complex, revealing dynamics of gp130 and the inhibitory mechanism of a cytokine variant.

bioRxiv · Jul 21, 2022Cell Biology

Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy - an in-silico study

S. Ghosh, G. Guglielmi, I. Orfanidis, F. Spill, A. Hickey, E. Hanssen, V. Rajagopal

This study uses computational modeling to show that disorganized mitochondrial and myofibrillar arrangement in diabetic cardiomyocytes leads to spatial variation in ADP/ATP ratios and increased inorganic phosphate concentration.

bioRxiv · May 22, 2022Cell Biology

MeasureIce: Accessible on-the-fly measurement of ice thickness in cryo-electron microscopy

H. G. Brown, E. Hanssen

MeasureIce measures ice thickness in cryo-EM grids to improve resolution by selecting optimal acquisition areas.

bioRxiv · Dec 8, 2021Biophysics

Novel virus-like particle vaccine encoding the circumsporozoite protein of Plasmodium falciparum is immunogenic and induces functional antibody responses

L. Kurtovic, D. Wetzel, L. Reiling, D. R. Drew, C. Palmer, B. Kouskousis, E. Hanssen, B. D. Wines, P. M. Hogarth, M. Suckow, V. Jenzelewski, M. Piontek, J.-A. Chan, J. Beeson

This paper describes a novel virus-like particle vaccine using duck hepatitis B virus surface antigen to display Plasmodium falciparum CSP, showing improved immunogenicity and functional antibody responses in mice.

bioRxiv · Dec 14, 2020Immunology

An Automated Workflow for Segmenting Single Adult Cardiac Cells from Large-Volume Serial Block-Face Scanning Electron Microscopy Data

A. Hussain, S. Ghosh, S. Beikoghli Kalkhoran, D. Hausenloy, E. Hanssen, V. Rajagopal

This paper introduces an automated algorithm to segment cardiac cell structures from SBF-SEM data, achieving 97% accuracy and enabling 3D finite element mesh generation for computational physiology studies.

bioRxiv · Jan 4, 2018Bioengineering