O. R. Burrone

This study identifies TRiC chaperonin as a component of rotavirus viroplasms essential for dsRNA synthesis and virus replication.

This study shows that rotavirus VP4 interacts with actin filaments to facilitate viroplasm assembly, using a recombinant virus with a modified VP4 to demonstrate the role of this interaction.

This paper engineers a recombinant rotavirus with a VP4-BAP tag, showing VP4's role in viroplasm stability and replication fitness.

This study shows rotavirus replication factories are RNA-protein condensates formed by phase separation, with unique features that could be targeted for antiviral therapies.

This study uses CRISPR-Csy4 to edit rotavirus dsRNA genome, enabling labeling of secondary transcription products and insights into viral replication.

This study uses reverse genetics to generate recombinant rotaviruses with NSP5 mutations, revealing that NSP5 hyperphosphorylation is essential for viroplasm assembly and viral replication.

This study shows that GBF1 is required for rotavirus replication by facilitating VP7 and NSP4 processing and virion assembly.