Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids.
S. Le Blanc, N. Ishaque, J. Jabs, T. Bauer, S. Schuth, Q. Hu, O. Debnath, F. W. Ten, C.-S. Leonhardt, A.-K. König, M. Bieg, C. Eckert, M. M. Gaida, M. Volkmar, D. Hübschmann, , O. Strobel
This study uses patient-derived PDAC organoids to integrate genomic, transcriptomic, and drug response data, identifying novel biomarkers and resistance mechanisms for personalized treatment.
bioRxiv · Aug 26, 2021 · PreprintCancer Biology