Author

K. Jechow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

C. Conrad· 4 shared R. Eils· 4 shared M. A. Schneider· 2 shared M. Meister· 2 shared M. Sprick· 2 shared A. Giri· 1 shared A. Jauch· 1 shared A. Trumpp· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCancer Biology

C. Conrad

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4 papers

Recent·Most cited

Intratumoural heterogeneity and immune modulation in lung adenocarcinoma of female smokers and never smokers

T. B. Trefzer, M. A. Schneider, K. Jechow, L. R. Chua, T. Muley, H. Winter, M. Kriegsmann, M. Meister, R. Eils, C. Conrad

The paper examines intratumoural heterogeneity and immune modulation in lung adenocarcinoma, focusing on female smokers and never smokers, identifying distinct cellular subpopulations and immune interactions.

bioRxiv · May 18, 2021Cancer Biology

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

T. G. Krieger, S. LeBlanc-Soto, J. Jabs, F. W. Ten, N. Ishaque, K. Jechow, O. Debnath, C.-S. Leonhardt, A. Giri, R. Eils, O. Strobel, C. Conrad

The paper uses single-cell RNA sequencing to analyze PDAC organoids and identifies conserved cell states and a differentiation hierarchy linked to tumor subtypes.

bioRxiv · Aug 23, 2020Cancer Biology

Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression

M. Waschow, Q. Wang, P. Saary, C. Klein, S. Aschenbrenner, K. Jechow, L. Maier, S. Tirier, B. Schoell, I. Chudoba, C. Dietz, D. Dreidax, A. Jauch, M. Sprick, C. Herrmann, , C. Conrad

This study shows that induced aneuploidy disrupts MCF10A acini formation and upregulates CCND1 expression through altered promoter-enhancer interactions.

bioRxiv · Dec 15, 2019 · PreprintCancer Biology

Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

J. Neugebauer, F. M. Zickgraf, J. Park, S. Wagner, X. Jiang, K. Jechow, K. Kleinheinz, U. H. Toprak, M. A. Schneider, M. Meister, S. Spaich, M. Suetterlin, M. Schlesner, A. Trumpp, M. Sprick, , C. Conrad

The paper compares drug responses in ovarian cancer organoids and monolayer cultures, finding differences in drug efficacy and genomic associations.

bioRxiv · Apr 6, 2017Cancer Biology