Q. Hu

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Reversible control of kinase signaling through chemical-induced dephosphorylation

This study uses an ABA-induced proximity system to reversibly control kinase signaling by recruiting phosphatases, revealing how phosphatases regulate oncogenic kinases like BCR::ABL1, BRAF(V600E), and MEK1.

Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase

The paper determines cryo-EM structures of human ACC1 in inactive and activated states, revealing structural dynamics and regulatory mechanisms.

Natural killer cell migration in HIV-infected individuals is inhibited by impairment of HIF-1alpha-mediated glycolysis

This study identifies that impaired NK cell migration in HIV-infected individuals is due to TIGIT inhibiting HIF-1-mediated glycolysis through PI3K/AKT/mTORC1 or ERK pathways.

Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)

The paper reports high-resolution cryo-EM structures of human PCC and MCC, revealing substrate binding modes and biotin coordination mechanisms.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

This study identifies two double mutations in SARS-CoV-2 3CLpro that confer resistance to the non-covalent inhibitor WU-04 and reveals trade-offs between catalytic activity, thermostability, and drug resistance.

Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors

This study shows that non-homologous end joining (NHEJ) is the main pathway causing complex genomic rearrangements during chromothripsis from mitotic errors.

Tandemly duplicated MYB genes specifically in the Phaseoleae lineage are functionally diverged in the regulation of anthocyanin biosynthesis

The paper investigates functional divergence of tandemly duplicated MYB genes in soybean, showing they regulate anthocyanin biosynthesis differently in various tissues.

Natural Circulation of Tick-borne Severe Fever with Thrombocytopenia Syndrome Virus in the City Ecosystem, China

The paper reports the natural circulation of SFTSV between Asian long-horned ticks and hedgehogs in Beijing, highlighting their role in maintaining the virus in the urban ecosystem.

Mitotic clustering of pulverized chromosomes from micronuclei

This study shows that acentric chromosome fragments from micronuclei cluster during mitosis, leading to biased inheritance and balanced chromothripsis in cancer.

RNA structures and dynamics with A resolution revealed by x-ray free electron lasers

This paper reveals RNA structures and dynamics at near-atomic resolution using x-ray free electron lasers, showing how RNA folds through intermediate states and forms triplexes.

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

This study identifies an autoinhibited state of 53BP1 stabilized by small molecule ligands, which shift its conformational equilibrium and inhibit chromatin recruitment.

Advancing Glycan Analysis: A New Platform Integrating SERS, Boronic Acids, and Machine Learning Algorithms

This paper introduces a glycan detection platform combining SERS, boronic acids, and machine learning to identify and quantify glycans with high accuracy.

Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis

This study shows that loss of ANT1 increases fibrosis and epithelial cell senescence in IPF by causing mitochondrial dysfunction.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

Chimeric mRNA based COVID-19 vaccine induces protective immunity against Omicron and Delta

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.

Hand Gesture Prediction via Transient-phase sEMG using Transfer Learning of Dilated Efficient CapsNet: Towards Generalization for Neurorobotics

This paper proposes a dilated efficient capsular neural network with transfer learning for hand gesture prediction using sEMG signals, showing improved performance with limited individual data.

A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development

This paper develops a chimpanzee adenovirus-based vaccine against the SARS-CoV-2 Delta variant and shows it induces strong immunity and protects mice from challenge.

X-MyoNET: Biometric Identification using Deep Processing of Transient Surface Electromyography

This paper introduces X-MyoNET, a deep learning model that uses transient surface electromyography (sEMG) signals for biometric identification, achieving 74% accuracy with a compact model.

The Flowering Repressor SVP recruits the TOPLESS co-repressor to control flowering in chrysanthemum and Arabidopsis

This study shows that SVP interacts with TPL to repress flowering by inhibiting FT gene expression in chrysanthemum and Arabidopsis, highlighting a conserved mechanism across species.

A novel mechanism of Euonymine inhibits in-stent restenosis through enhancing contractile phenotype of VSMCs by targeting AKT1 and p38MAPK

Deep Heterogeneous Dilation of LSTM for Transient-phase Gesture Prediction through High-density Electromyography: Towards Application in Neurorobotics

This paper introduces heterogeneous temporal dilation in LSTM for transient-phase gesture prediction using HD-sEMG, achieving state-of-the-art accuracy, faster training, and better convergence.

Remarkable Adsorption Performance of Rutile TiO2 (110) Nanosheet for DNA Nucleobases: A First-Principles Study

This study uses first-principles calculations to show rutile TiO2 (110) nanosheets have strong adsorption for DNA nucleobases, exceeding graphene by over 20 times, with implications for DNA sensors and sequencers.

Short-term instantaneous prophylaxis and efficient treatment against SARS-CoV-2 in hACE2 mice conferred by an intranasal nanobody (Nb22)

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

Single cell RNA Sequencing Identifies G-protein Coupled Receptor 87 as a Novel Basal Cell Marker of Distal Honeycomb Cysts in Idiopathic Pulmonary Fibrosis

The paper identifies GPR87 as a novel marker for KRT5+ basal cells in IPF distal bronchioles and honeycomb cysts using single-cell RNA sequencing.

Structure and ion-release mechanism of PIB-4-type ATPases

The paper presents structures and functional analyses of a PIB-4-type ATPase, revealing novel mechanisms of heavy-metal transport and potential drug targets.

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids.

This study uses patient-derived PDAC organoids to integrate genomic, transcriptomic, and drug response data, identifying novel biomarkers and resistance mechanisms for personalized treatment.

Directing an mRNA-LNP vaccine toward lymph nodes improves humoral and cellular immunity against SARS-CoV-2

This study develops an mRNA-LNP vaccine (STI-7264) and a lymphatic delivery device (MuVaxx) that enhance immune responses against SARS-CoV-2 with reduced dosing.

NNAL, a major metabolite of tobacco-specific carcinogen NNK, promotes lung cancer progression through deactivating LKB1 in an isomer-dependent manner

This study shows that (R)-NNAL promotes lung cancer progression by deactivating LKB1 through β-AR signaling, while (S)-NNAL has weaker effects.