P. A. Larsen

Microfluidic Quaking-Induced Conversion (Micro-QuIC) for Rapid On-Site Amplification and Detection of Misfolded Proteins

This paper introduces Micro-QuIC, a microfluidic platform for rapid detection of misfolded proteins, demonstrating faster amplification and visual detection of CWD compared to RT-QuIC.

Self-organized emergence of hyaline cartilage in hiPSC-derived multi-tissue organoids

This study develops a protocol for generating hyaline cartilage from hiPSC-derived multi-tissue organoids and identifies molecular pathways involved in its self-organized emergence and articular cartilage development.

Enabling metagenomic surveillance for bacterial tick-borne pathogens using nanopore sequencing with adaptive sampling

This paper demonstrates the use of nanopore adaptive sampling to selectively sequence bacterial tick-borne pathogens from Ixodes scapularis ticks, increasing targeted pathogen sequences by two-fold.

Molecular surveillance of zoonotic bacterial pathogens in farm dwelling peridomestic rodents across the upper Midwest, USA

This study surveys zoonotic bacterial pathogens in farm rodents using metagenomics, finding multiple foodborne pathogens in various rodent species and shrews.

Comparison of Chronic Wasting Disease Detection Methods and Procedures: implications for free-ranging white-tailed deer (Odocoileus virginianus) surveillance and management

This study compares CWD detection methods in white-tailed deer, finding RT-QuIC more sensitive than ELISA and IHC, and that testing multiple tissues improves detection rates.

Integrating indigenous knowledge, ontology, and molecular barcoding to characterize spider monkey (Ateles paniscus) filariasis

The paper integrates indigenous knowledge, ontology, and molecular barcoding to characterize a filarial nematode in spider monkeys, finding it non-zoonotic and consistent with local beliefs.

Pedigree-based measurement of the de novo mutation rate in the gray mouse lemur reveals a high mutation rate, few mutations in CpG sites, and a weak sex bias

The paper estimates the de novo mutation rate in gray mouse lemurs using linked-read sequencing and finds a high mutation rate, few mutations in CpG sites, and a weak sex bias.

Cryptic patterns of speciation in cryptic primates: microendemic mouse lemurs and the multispecies coalescent

The paper investigates species boundaries in mouse lemurs using multispecies coalescent methods, finding that some previously recognized species are not distinct while an undescribed lineage is supported as a new species.