S. Stone

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Generation and characterization of a multi-functional panel of monoclonal antibodies for SARS-CoV-2 research and treatment

This paper generates and characterizes three monoclonal antibodies against SARS-CoV-2 RBD, showing varying efficacy in neutralization and detection assays.

CADD from Chlamydia trachomatis is a manganese-dependent oxygenase that employs a self-sacrificing mechanism for the synthesis of p-aminobenzoate

This study characterizes CADD from Chlamydia trachomatis as a manganese-dependent oxygenase using self-sacrificing tyrosine and lysine residues for p-aminobenzoate synthesis.

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing mice

This study compares the pathogenesis of SARS-CoV-2 variants in human ACE2-expressing mice, finding that some variants are more lethal and replicate more in the lungs and brain.

Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses

This study develops a hybrid vaccine combining influenza VLPs with SARS-CoV-2 RBD and GM-CSF, showing protection against both viruses in mice.

SARS-CoV-2 variants of concern infect the respiratory tract and induce inflammatory response in wild-type laboratory mice

This study infects wild-type mice with SARS-CoV-2 variants to show B.1.1.7 and B.1.351 replicate more efficiently and induce stronger inflammatory responses than the original B.1 virus.

Comparison of Chronic Wasting Disease Detection Methods and Procedures: implications for free-ranging white-tailed deer (Odocoileus virginianus) surveillance and management

This study compares CWD detection methods in white-tailed deer, finding RT-QuIC more sensitive than ELISA and IHC, and that testing multiple tissues improves detection rates.

Neuroinvasion and encephalitis following intranasal inoculation of SARS-CoV-2 in K18-hACE2 mice

This study shows that SARS-CoV-2 causes neuroinvasion and encephalitis in K18-hACE2 mice, leading to 100% mortality by day 6 post-infection.

The FDA-approved gold drug Auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells

This study shows that auranofin inhibits SARS-CoV-2 replication and reduces inflammation in human cells, suggesting its potential as a therapeutic option for COVID-19.