A. Rossi

Human monoclonal antibodies reveal subdominant gonococcal and meningococcal cross-protective antigens

The paper identifies human monoclonal antibodies that recognize key antigens, PorB and LOS, providing cross-protection against gonococcal and meningococcal infections.

Multivariate models of animal sex: breaking binaries leads to a better understanding of ecology and evolution

This paper argues for a multivariate model of sex to better understand ecological and evolutionary processes by analyzing case studies and a meta-analysis of sexual phenotype terminology.

Data-driven characterization of Preterm Birth through intramodal Diffusion MRI

This study uses diffusion MRI techniques to identify markers of preterm birth by comparing preterm and term neonates using statistical and machine learning methods.

Human coronaviruses activate and hijack the proteostasis guardian HSF1 to enhance viral replication

This study shows that human coronaviruses activate HSF1 to enhance replication, suggesting HSF1 as a potential antiviral target.

The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoprotein

The paper shows nitazoxanide inhibits seasonal coronaviruses by interfering with spike glycoprotein maturation, not affecting viral entry.

Spike mutation resilient scFv76 antibody counteracts SARS-CoV-2 lung damage upon aerosol delivery

The paper shows that scFv76 antibody neutralizes multiple SARS-CoV-2 variants and reduces lung damage in mice when delivered via aerosol.

m6A reader Pho92 is recruited co-transcriptionally and couples translation efficacy to mRNA decay to promote meiotic fitness in yeast

Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses

This study identifies that PGE2-EP2 signaling suppresses lung ILC2 responses and eosinophilic inflammation, while EP4 agonism restricts these responses, offering potential therapeutic targets for asthma and NERD.

Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara express-ing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells

Rest/Stress Myocardial Perfusion Imaging by Positron Emission Tomography with 18F-Flurpiridaz: A Feasibility Study in Mice

This study evaluates the feasibility of rest/stress PET-MPI with 18F-flurpiridaz in mice, finding that myocardial uptake correlates with perfusion parameters and enables CFR estimation.

Cellular-level phenotyping of tumor-immune microenvironment (TiME) in patients in vivo reveals distinct inflammation and endothelial anergy signatures

The paper uses in vivo cellular-level imaging to phenotype tumor-immune microenvironments, identifying distinct inflammation and endothelial anergy signatures linked to immunotherapy response.

Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy

This study identifies human antibody fragments that neutralize SARS-CoV-2 variants and show efficacy in animal models, suggesting potential for early COVID-19 therapy.

Fungal extracellular vesicles are involved in intraspecies intracellular communication

This study shows fungal extracellular vesicles mediate intraspecies communication by regulating gene expression and phenotypic changes in Candida albicans, Aspergillus fumigatus, and Paracoccidioides brasiliensis.

Impairment of SARS-CoV-2 spike-glycoprotein maturation and fusion-activity by nitazoxanide: an effect independent of spike variants emergence

This study shows nitazoxanide impairs SARS-CoV-2 spike maturation and fusion activity, effective against multiple variants including Delta.

The outcome of neutrophil-T cell contact differs depending on activation status of both cell types

This study investigates how the activation status of neutrophils and T cells affects their interaction outcomes, finding that resting neutrophils suppress T cell responses while de-granulating neutrophils do not.

Molecular mechanisms of LC3-associated phagocytosis in the macrophage response to Paracoccidioides spp.

This study investigates the role of LC3-associated phagocytosis in macrophage response to Paracoccidioides spp., finding that autophagy is important for antifungal activity and that signaling pathways differ from other fungi.

The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection

This study identifies ErsA as a small RNA that regulates Pseudomonas aeruginosa virulence traits and contributes to host inflammatory responses and antibiotic resistance during chronic infections.

Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCR?-chain, which highlights the immunopathological aspect of the disease

The paper examines Treg cell subsets and TCRβ clonotypes in alopecia areata patients, finding reduced FOXP3+CD39+ Tregs and specific clonotypic differences that suggest potential therapeutic targets.